Most of those are normal and OK, since they are from Google, Mozilla (Firefox), Facebook, and Twitter. They are simply the normal operating connections/communications to use those apps/services. If you hit Deny - Any Connection - Forever, you may end up blocking your access to some Internet services.
The numbers are the ports the services are using: 80 is Internet/HTTP/web, 443 is secured Internet/HTTP/web. The only two you may have wanted to block are: s,skimresourses.com 80 and pagead46.doubleclick.net 80. While not harmful to your Mac, they are simply connections back to Internet ad services, wich track how many visitors there are to a website.
-Did you purchase Little Snitch, or is it a trial?
-Was there a specific need to install it?
Most general users can be totally overwhelmed by the number of alerts, and if they block the wrong ones, it will slowly cause their Mac to not function properly with network and Internet services. Because of that, I usually only recommend that folks with more advanced knowledge install it. If you are unsure about a connection, you could try denying Once, to see if you are blocked from something you use. During an Internet browsing session, you can easily have hundreds of pop-ups and decisions to make.
If you are trying to block Internet pop-up ads/ads on webpages, things like
uBlock and
Adblock Plus are better for that, as they are automated and basically require no user interaction.
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