Hello and welcome.
-Which model Mac?
-Which version of OS X/macOS?
-What kind of cleaning are you trying to perform?
As always, it is strongly recommended to have a current Time Machine or other backup of your data.
Honestly, I personally don't use any of the third-party cleaning applications. You can manually clean out files in your User folder. For applications that you want to remove, I would recommend FreeMacSoft -
AppCleaner, as it will identify and remove all of the hidden/related files for applications in one fell swoop.
C