OK, thanks for the additional.
I also have an EyeTV, but it is an older model made before Geniatech purchased the technology from Elgato. I never really used the TV Guide part of the software, as it was used to transfer VHS tapes into digital format.
I assume the file you are referring to is named something like com.geniatech.schedule.plist or com.elgato.guide.plist?
As I mentioned previously, plist files are normally written by software, when preferences or settings are set in the application. Since they are basically text files, normally they can be deleted, and they will be recreated when the application is launched again and preferences/settings are changed. Sometimes, deletion of plist files ca help certain issues users are having, as they can get "corrupted" from time to time.
I hope that helps, and please let us know if there is a particular issue you are having.
C